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KMID : 0616120100410040245
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Korean Journal of Pharmacognosy
2010 Volume.41 No. 4 p.245 ~ p.249
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Antioxidant Constituents of the Heartwood of Cedrela sinensis A. Juss
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Park Sae-Rom
Yang Seok-Won
Ahn Dal-Rae
Yang Jae-Heon
Cho Chong-Hyeon
Kim Hak-Yong
Lee Jae-Hyeok
Park Jeong-Suk
Kim Dae-Keun
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Abstract
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As part of ongoing study focused on the discovery of natural antioxidants from Korean plants by measuring the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging effect and superoxide quenching activity, methanol extract of Cedrela sinensis (Meliaceae) was found to show potent antioxidant activities. Subsequent activity-guided fractionation of the methanolic extract led to the isolation of four phenolic compounds, (+)-catechin (1), (-)-epicatechin (2), catechin-(4α→8)-catechin (3) and catechin-(4α→8)-epicatechin (4). Their structures were elucidated by spectroscopic studies. These compounds showed the significant antioxidative effects on DPPH. In riboflavin originated superoxide quenching activity, four compounds exhibited the formation of the blue formazan in a dose dependant manner.
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KEYWORD
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Cedrela sinensis, Meliaceae, DPPH, Superoxide quenching activity
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